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When searching PubMed for Serrapeptase, one can find close to 40 clinical studies, most of which are from European or Asian researchers, since Serrapeptase has not hit the mainstream in the U.S. The studies, on the whole, conclude that Serrapeptase can have tremendous benefits.

1. For example, one multi-center, double-blind, randomized trial done at the Institute of Clinical Otorhinolaryngology at the University of Naples, in Italy, found that Serrapeptase acted as an effective anti-inflammatory to improve ear, nose and throat disorders, and the supplement reduced pain. The study, which used 193 people and lasted eight days, also found that Serrapeptase caused no significant side effects.

2. Another multi-center, double-blind study, published in the journal, Pharmatherapeutica, found that Serrapeptase reduced swelling in patients who underwent surgery to treat empyema (a collection of pus in the cavity between the lung and the membrane that surrounds it). This study included 174 patients and showed no adverse side effects. Another study involving post-operative swelling, and done by German researchers, showed that patients who had ankle surgery and were given Serrapeptase had a 50% reduction in swelling, while those patients who did not receive Serrapeptase had no reduction in swelling. Patients taking the supplement were also relieved of all pain by the tenth day after surgery.

3. A small study (involving 20 patients) done over a period of six weeks and published in the Journal of the Association of Physicians in India, found that Serrapeptase may help improve carpal tunnel syndrome. No significant side effects were observed.

4. Another use for Serrapeptase involves the treatment of fibrocystic breast disease. In one double-blind study published in the Singapore Medical Journal, 70 women with breast engorgement were randomly divided into a treatment and placebo group. There was more reduction of breast pain and swelling in the women receiving Serrapeptase than there was for the women who did not receive the supplement. Again, no adverse reactions were reported.

5. As for the cardiovascular benefits of Serrapeptase, the evidence supporting this is mostly anecdotal and based in large part on the research of the late Hans A. Nieper, M.D., an internist from Hannover, Germany, who is widely known and also considered antiestablishment. He studied the effects of Serrapeptase on plaque accumulations in the arteries. A book about Dr. Nieper’s work, entitled, The Curious Man: The Life and Works of Dr. Hans Nieper (Avery Penguin Putnam, December 1998), provides insight into his studies. An Italian study done at the University of Naples in the department of vascular surgery, did show that Serrapeptase was effective and well tolerated in patients with inflammatory venous diseases. But more research is necessary to accurately and specifically determine the effects Serrapeptase can have on cardiovascular health.

Safety

As with every substance one consumes (from food to pills), there is the potential for risk. Just because something is “natural” doesn’t mean it is automatically harmless. Certainly, the ongoing and recent controversy over the regulation of nutritional supplements indicates that one needs to be cautious and informed when using any supplement. While naturally derived supplements can be beneficial and safe, they can also be harmful if used carelessly or without the help of a medical professional.

That said, Serrapeptase is a powerful enzyme that comes with a few cautions. In elderly people who use the product over a long period of time, gastrointestinal irritation can occur, though this is rare. There is also the increased risk of infection of the lung and pneumonia when using Serrapeptase. This is rare (as evidenced by a few isolated letters to the editor in medical journals) but is a possibility because Serrapeptase thins mucus secretions, which can lead to lung complications if one has a history of lung problems. Also note that the studies involving Serrapeptase do not extend over a long period of time. Therefore, the long-term effects of this supplement have not yet been determined.

Dosage

The recommended dose is 10 mg to 30 mg per day. For prevention, 10 mg daily. For arthritis, sinusitis, fibrocystic breast, bronchitis and cardiovascular problems, 20 mg daily. For pain, start with 10 mg daily and work up to 20 mg if needed. For injury, trauma or post surgery recovery, take 30 mg daily for two days, then go down to 20 mg daily until swelling and pain subside. Be sure to take Serrapeptase on an empty stomach, meaning that Serrapeptase should be taken at least two hours after eating, and no food should be consumed for a half hour after taking it.

It is important to note that not all Serrapeptase products are created equal. The enzyme activity is measured in units and clinical studies are based on the ratio of 10 mg of Serrapeptase equaling 20,000 units of activity. When purchasing the product be sure that the ratio of mg to units is 10 mg for every 20,000 units, or 5 mg for 10,000 units and so on. The average dose, therefore, is 20 mg–or 40,000 units.

As with many medications, there are always the side effects of it. Here are a few things to consider when taking Serrapeptase:

1. Serrapeptase has undergone various amounts of research and tests to find out its compatibility with the human body and what other benefits this enzyme can bring. As of May, 2009, Serrapeptase has shown no serious, life threatening or long term side effects in clinical trials or in public use. Some of the minor side effects from the use of Serrapeptase from a few patients is that they have reported a skin rash, mild headache, stomach discomfort and other minor aches and pains. However, the symptoms were mild in nature and disappeared after a few days. Researchers concluded that this is a way of the body reacting to something foreign until it gets used to the new drug.

History

2. Japanese scientists were the people who founded Serrapeptase and this enzyme was found and discovered deep inside the intestines of the silk worm. This enzyme was produced in the intestines of the silk worms that then used it to break open from their cocoon after the evolution to a butterfly took place. With the popularity of Serrapeptase increased, however, the depletion of the worm’s population could not meet the increased demand for the drug. This has led to an insufficient harvest quantity. Now serratia peptidase, which comes from the fermentation of enterobacteria known as Serratia E15, is used instead. This version is a more synthetically produced version of Serrapeptase.

Function

3. Serrapeptase can digest arterial plaque, blood clots, cysts and dead tissue within the body. It is more commonly favored by health practitioners and doctors as it does not do any harm to living cells and tissue. Because it can digest arterial plaque, it is a very useful drug to combat and prevent certain heart conditions such as heart attacks as well as stroke.

Benefits

4. Serrapeptase is nature’s gift for a natural solution to anti-inflammatory medications. It is also been reported that serrapeptase has a much more effective result in treating pain compared to NSAIDs according to Physician Formulas. Apart from it being used to treat inflammation related diseases and injuries, serrapeptase is also used to treat asthma, carpal tunnel syndrome, cluster headache, Chohn’s disease, colitis, cystitis, emphysema, enlarged prostate and many other conditions.

Significance

5. Serrapeptase is a relatively new drug in the medicine world and thus on going research is being conducted to find more of its benefits as well as if there are any other side effects other than what has been reported. Though that, current research has shown that it could eliminate serious medical conditions related to the hardening of artery walls. Also, serrapeptase can help in postoperative medical and dental treatment because of its ability to reduce swelling.

Research by the Clinical Otorhinolaryngology at the University of Naples

A multi center, double blind, randomized trial was done which found that Serrapeptase acted as an effective anti-inflammatory agent that improved ear, nose and throat disorders and also showed that it reduced pain and caused no significant side effects. The study used 193 people and lasted eight days.

Study Published in Pharmatherapeutica Journal

This is another multi-center double blind study that found Serrapeptase reduced swelling in patients who underwent surgery to treat empyema. This study included 174 patients and it also showed no side effects. German researchers also did a study on post-operative swelling which was published in the journal that showed patients who had ankle surgery and who were administered Serrapeptase had a 50% reduction in swelling compared to patients that were not treated with Serrapeptase. Patients taking the supplement were also relieved of all pain by the tenth day after surgery.

Study Published in the Journal of the Association of Physicians, India

One study which involved 20 patients over a period of six weeks found that Serrapeptase also helped improve symptoms of Carpal Tunnel Syndrome and there were no side effects to the patients under the study. Serrapeptase also has sped up the recovery process for fibrocystic breast disease. This study was published in the Singapore Medical Journal which involved 70 women with breast engorgement. The 70 women were divided into a placebo group and a group that would receive treatment. Results show that those who went for treatment recovered faster and there was reduction in breast pain and swelling compared to the women who did not receive treatment. The study also did not show any side effects occurring.

Dr. Hans A. Neiper

Dr. Hans’s research and discovery is by far the most famous of all. A medical doctor from Hannover, Germany, Dr. Hans studied the effects of Serrapeptase on plaque accumulations in the arteries. A book he wrote entitled The Curious Man: The Life and Works of Dr. Hans Nieper (Avery Penguin Putnam, December 1998), records insights to his findings and shown that Serrapeptase was indeed effective and well tolerated in patients with inflammatory venous diseases.

More and more research is being conducted to accurately and specifically determine effects, benefits and uses of Serrapeptase. Safety though has to be practiced with anything and everything you consume whether it is food or pills. Anything in excess or less is harmful to the body. The ongoing debate on the regulation of nutritional supplements tells you that caution needs to be practiced when consuming pills of any kind. While natural supplements have fewer risks to the body, it can be harmful if taken without proper medical professional advice.